The Epistatic Interrelationships of IL-1, IL-1 Receptor Antagonist, and the Type I IL-1 Receptor

The epistatic interrelationships of IL-1, IL-1 receptor antagonist, and the type I IL-1 receptor.

Mice lacking the gene for the IL-1R antagonist (IL-1ra) show abnormal development and homeostasis as well as altered responses to infectious and inflammatory stimuli. A reduction in the level of IL-1 signaling, either by deletion of the receptor or increased expression of IL-1ra, does not affect development or homeostasis, but does alter immune responses. In this study we use genetic epistasis ...

The Pattern of Interleukin-1/3 (IL-1/3) and Its Modulating Agents IL-1 Receptor Antagonist and IL-1 Soluble Receptor Type II in Acute Meningococcal Infections

The Pattern of Interleukin-1/8 (IL-1/3) and Its Modulating Agents IL-1 Receptor Antagonist and IL-1 Soluble Receptor Type II in Acute Meningococcal Infections

Effect of Interleukin-1 (IL-1) Blockade on Cytokine Synthesis: I. IL-1 Receptor Antagonist Inhibits IL-1-Induced Cytokine Synthesis and Blocks the Binding of IL-1 to Its Type I1 Receptor on Human Monocytes

Interleukin-1 (IL-1) induces IL-1, tumor necrosis factor a (TNFa), and IL-6 gene expression and synthesis in a variety of cells. In this study, we investigated the ability of human recombinant IL-1 receptor antagonist (IL-lra) to inhibit IL-1induced cytokine production in human peripheral blood mononuclear cells (PBMC) and isolated monocytes. IL-lra alone at concentrations as high as 1 pg/mL di...

Glucocorticoid in Murine Hepatocytes Expression and IL-1 Signaling by IL-6 and Augmentation of Type I IL-1 Receptor